The 2-Minute Rule for paralgin forte reseptfritt
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Maternally toxic doses which were about seven moments the maximum suggested human dose of 360 mg/day, ended up affiliated with evidence of bone resorption and incomplete bone ossification. Codeine didn't show evidence of embrytoxicity or fetotoxicity within the rabbit model at doses up to 2 times the most proposed human dose of 360 mg/working day according to a system area area comparison . Nonteratogenic effects
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Induksjon av metabolismen av paracetamol i lever, både til inaktive metabolitter og til den levertoksiske metabolitten NAPQI.
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This drug is classed to be a pregnancy Category C drug. There aren't any ample and perfectly-managed studies completed in Expecting Females. Codeine should really only be used all through pregnancy In case the possible gain outweighs the opportunity chance with the drug to your fetus . Codeine has demonstrated embryolethal and fetotoxic results within the hamster, rat in addition to mouse designs at about 2-four periods the utmost advised human dose .
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Plasma 50 percent-life of codeine and its metabolites have already been described to generally be around 3 hours . Clearance
Hvor stor er en farlig dose kodein? Dette varierer mye fra human being til human being. Grunnen til dette er at de som bruker det ofte og mye utvikler toleranse for kodein. En annen grunn er individuelle forskjeller i hvor stor del av kodeinet som omdannes til morfin i kroppen.
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Nedsatt konsentrasjon av aktiv metabolitt av kodein, risiko for nedsatt analgetisk effekt av kodein (fremfor alt med tanke på at pasienter som bruker metadon allerede har utviklet opioidtoleranse).